Antifungal activity of bamemacrolactine C against <i>Talaromyces marneffei</i> and its possible mechanisms of action
The findings suggest that BAC exhibits antifungal activity against T. marneffei, elucidating its multifaceted mechanism of action involving disruption of cell membranes' integrity and inhibition of intracellular enzyme activities, in which the modulation of ACLY in the TCA cycle may play an important role.
Authors
- Xinjian Qu
- Xiangxi Yi (ORCID: https://orcid.org/0000-0002-8251-8836)
- Guangfu Feng (ORCID: https://orcid.org/0000-0001-7335-166X)
- Chenghai Gao (ORCID: https://orcid.org/0000-0002-7524-8049)
- Zhou Wang (ORCID: https://orcid.org/0009-0002-5003-5757)
- Yonghong Liu (ORCID: https://orcid.org/0000-0001-8327-3108)
- Kai Liu (ORCID: https://orcid.org/0000-0001-7034-7235)
- Cuiping Jiang (ORCID: https://orcid.org/0000-0001-9694-5399)
Institutions
- Guangxi University (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1093/jambio/lxae297
- Citations
- 1
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- National Natural Science Foundation of China
- Guangxi Traditional Chinese Medical University