P133 Evaluation of serum uric acid among the patients with psoriasis

Abstract Background Psoriasis is a common papulosquamous, chronic inflammatory skin disorder, clinically characterized by sharply demarcated erythematous plaques covered by silvery-white scales preferentially on the extensor surface of upper extremities, knee, scalp, umbilicus and lumbar area. Studies have shown that psoriasis can progress to systemic involvement like psoriatic arthritis, metabolic syndrome, uric acid and lipid metabolism derangement. The aim of this study was to evaluate serum uric acid levels among patients with psoriasis. Method From the outpatient department of the department of Dermatology of Bir Hospital and Shree Birendra Hospital, Chhauni, Kathmandu. One hundred and thirty-eight patients were enrolled in the study. Among them 69 (male = 36 and female = 33) with psoriasis were selected as case, 69 patients with other dermatologic diseases after matching age and sex were selected as controls. Informed written consent, after a detailed history and physical examination, body mass index (BMI) and psoriasis area and severity index (PASI) of cases were calculated and they were sent for serum uric acid investigation. The serum uric acid level was determined for both cases and controls. Results Chronic plaque psoriasis was the most common 60 (87.0%) variant and there was no significant association between psoriasis type and sex. The male–female ratio was 1.09:1. Majority of the psoriasis patients (76%) were among the younger population and most of them (91.3%) had normal serum uric acid levels. Most of the patients 55 (79.7%) did not have a family history of psoriasis. Patients 58 (84.1%) had a history of flare up in the winter season. Body mass index was found to be normal range in most 65 (94.2%) of the patients. Among the control group, eczema was the most common 16 (23%) diagnosis and most of the patients (91.3%) had normal serum uric acid levels. No significant association between psoriasis area severity index score and serum uric acid level was found in the study (P = 0.81). Conclusion In our study, serum uric acid was more significant among psoriasis patients than the control group. Most of the patients had aggravating psoriasis in the winter season. However, it was not also significant with psoriasis area and severity index, this may be due to psoriasis lesions were not severe or extensive body surface area involvement and no systemic complication issues. However, we have to rule out other systemic complications due to psoriasis in long-term follow-up.