P27 The state of the skin microbiome in patients with psoriasis

Abstract In dermatological practice, in the pathogenesis of chronic dermatoses, much attention is paid to the state of the skin microbiome. According to research, the role of superantigens—protein substances—bacterial toxins of staphylococcal, streptococcal nature, as well as fungi of the genus Candida, takes place in the pathogenesis of psoriasis. The purpose of our research was to assess the state of the skin microbiome in patients with psoriasis. Research materials and methods We examined 94 patients with psoriasis aged 12–69 years who received inpatient treatment at the Dermatological Department of the Research Dermatology Centre of Clinic of the Ministry of Health of the Republic of Uzbekistan. Taking into account gender, 40 patients were male and 54 were female. Clinical, biochemical, microbiological and statistical studies were conducted in all patients. The control group consisted of 72 healthy individuals of the appropriate age. The results of the study Microbiological studies of the skin in patients with psoriasis have shown a high detectability of opportunistic microorganisms of the Micrococaccea family—staphylococcus spp., which amounted to 62.7% of cases. Taking into account the clinical course of dermatosis, frequent seeding of opportunistic microflora was noted in the progressive stage—72.8%, whereas in the stationary stage—27.1%, respectively. According to the species identification of staphylococci in the examined patients, Staphylococcus epidermidis was most often sown—S. epidermidis was most often sown—32.2% and Staphylococcus haemoliticus—27.1%, Staphylococcus aureus—23.7% of cases. Cases with increased colonization caused the development of the syndrome of colonization resistance of opportunistic microorganisms. Conclusion Thus, the results obtained indicate that the role of opportunistic microorganisms in the clinical course of psoriasis is of clinical importance, the degree of colonization plays an important role in the pathogenesis of psoriasis, causing the development of the syndrome of colonization resistance of opportunistic microorganisms on the skin of patients.