Association Between the Sequence of β-Lactam and Vancomycin Administration and Mortality in Patients With Suspected Sepsis
Among patients with suspected sepsis prescribed vancomycin and β-lactam therapy, β-lactam administration before vancomycin was associated with a modest reduction in in-hospital mortality. These findings support prioritizing β-lactam therapy in most patients with sepsis but merit confirmation in randomized trials given the risk of residual confounding in observational analyses.
Authors
- Laura DelloStritto
- Michael Klompas (ORCID: https://orcid.org/0000-0001-8641-4498)
- Theodore R. Pak (ORCID: https://orcid.org/0000-0002-1676-2523)
- Chanu Rhee (ORCID: https://orcid.org/0000-0002-9537-4245)
- Caroline McKenna (ORCID: https://orcid.org/0009-0000-1093-3080)
- Claire Shappell (ORCID: https://orcid.org/0000-0002-8316-1496)
- Yutaka Kondo (ORCID: https://orcid.org/0000-0003-1072-7089)
Institutions
- Brigham and Women's Hospital (US)
- Juntendo University (JP)
- Massachusetts General Hospital (US)
- Harvard Pilgrim Health Care (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1093/cid/ciae599
- Citations
- 3
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16