Let it shine: Autofluorescence of Papanicolaou-stain improves AI-based cytological oral cancer detection

This study advances the field of cytopathology by integrating deep learning methods, multimodal imaging and information fusion to enhance non-invasive early detection of oral cancer. Our approach not only improves diagnostic accuracy, but also allows an efficient, yet uncomplicated, clinical workflow. The developed pipeline has potential applications in other cytological analysis settings. We provide a validated open-source analysis framework and share a unique multimodal oral cancer dataset to support further research and innovation.