Total Synthesis and Stereochemical Assignment of Roselipin 1A
Roselipin 1A, a bioactive natural glycolipid isolated from marine fungal metabolites, presents an unresolved configuration of its nine stereogenic centers within the polyketide chain. Herein, we elucidate the comprehensive stereostructure of roselipin 1A through an integrative approach combining predictive rule-guided analysis with synthetic chemistry. The efficient total synthesis facilitated the unequivocal confirmation of the hypothesized stereochemistry for roselipin 1A, thereby establishing its precise molecular configuration.
Authors
- Yian Guo (ORCID: https://orcid.org/0000-0002-0341-6816)
- Tao Ye (ORCID: https://orcid.org/0000-0002-2780-9761)
- Junyang Liu (ORCID: https://orcid.org/0000-0002-4622-5200)
- Yangyang Jiang (ORCID: https://orcid.org/0009-0005-8724-313X)
Institutions
- Peking University (CN)
- Lifetech Scientific (China) (CN)
- Peking University Shenzhen Hospital (CN)
- Wuyi University (CN)
Publication Details
- Journal
- Precision Chemistry
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1021/prechem.4c00082
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Department of Education of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province