Shared Genetics of Migraine and Gastrointestinal Disorders Implicates Underlying Neurologic Mechanisms Yet Heterogeneous Etiologies
Genetic sharing of migraine and non-immune-related GI disorders was extensive yet distinct across GI disorders that have overlapping symptoms, with enrichment signals that imply neurologic mechanisms. Causal effects of some GI conditions on migraine were supported. A concordant local correlation at <i>CALCA/CALCB</i> of migraine with both DD and the immune-related disorders suggests potential benefit to these conditions from repurposed migraine therapeutics targeting CGRP.
Authors
- Pamela M. Rist (ORCID: https://orcid.org/0000-0003-3543-045X)
- Daniel I. Chasman (ORCID: https://orcid.org/0000-0003-3357-0862)
- Andrew T. Chan (ORCID: https://orcid.org/0000-0001-7284-6767)
- Kyle Staller (ORCID: https://orcid.org/0000-0003-4925-4290)
- Yanjun Guo (ORCID: https://orcid.org/0000-0002-5927-778X)
Institutions
- Brigham and Women's Hospital (US)
Publication Details
- Journal
- Neurology Genetics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1212/nxg.0000000000200201
- Citations
- 4
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.54
Funders
- Brigham and Women's Hospital
- Massachusetts General Hospital
- Helsingin Yliopisto
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Harvard T.H. Chan School of Public Health
- Wellcome Trust
- QIMR Berghofer Medical Research Institute
- Broad Institute
- King's College London
- University of Oxford
- University of Bristol
- Institut National de la Santé et de la Recherche Médicale
- Universiteit Leiden
- Rijksuniversiteit Groningen
- Vrije Universiteit Amsterdam
- Karolinska Institutet
- Landspítali Háskólasjúkrahús
- Novo Nordisk
- Tampereen Yliopisto
- Samfundet Folkhälsan
- Universitair Medisch Centrum Groningen
- Rigshospitalet
- Universitetet i Oslo
- Ludwig-Maximilians-Universität München
- Oulun Yliopisto
- Université de Bordeaux
- Tartu Ülikool
- Universität Ulm
- Terveyden ja hyvinvoinnin laitos
- Stanley Center for Psychiatric Research, Broad Institute
- Medical Research Council
- Statens Serum Institut
- Erasmus Universitair Medisch Centrum Rotterdam
- Norwegian Institute of Public Health
- Institute of Genetics