Histological, But Neither Clinical Nor Endoscopic Activity Predicts the Risk of Colectomy in Patients With Ulcerative Colitis Treated With Biologics
Severe histological activity at baseline as characterized by a higher Nancy Index or Geboes score independently predicted colectomy risk in biological-treated UC patients, whereas MES did not. Thus, histological assessment should be encouraged before initiating biological treatment.
Authors
- Pernille Dahlin (ORCID: https://orcid.org/0000-0001-5514-2979)
- Johan M. Burisch (ORCID: https://orcid.org/0000-0002-3312-5139)
- Pernille Dige Ovesen (ORCID: https://orcid.org/0000-0001-5513-2914)
- Mirabella Zhao (ORCID: https://orcid.org/0000-0002-8392-4860)
- Jakob Benedict Seidelin (ORCID: https://orcid.org/0000-0003-3230-7966)
- Mohamed Attauabi (ORCID: https://orcid.org/0000-0003-0323-7030)
- Lone Larsen (ORCID: https://orcid.org/0000-0003-4067-2381)
- Christian Lodberg Hvas (ORCID: https://orcid.org/0000-0001-7973-7184)
- Andreas Munk Petersen (ORCID: https://orcid.org/0000-0003-0531-0553)
- Dagmar Christiansen
- Flemming Bendtsen (ORCID: https://orcid.org/0000-0002-8419-2104)
- Zainab Gassem Nagras (ORCID: https://orcid.org/0000-0002-6993-5424)
- Anders Dige (ORCID: https://orcid.org/0000-0001-9995-0329)
- Bobby Zhao Sheng Lo (ORCID: https://orcid.org/0000-0002-0252-9341)
- Mads Damsgaard Wewer (ORCID: https://orcid.org/0000-0001-9140-9706)
- Lene Riis (ORCID: https://orcid.org/0000-0003-4669-3159)
- Anja Poulsen (ORCID: https://orcid.org/0000-0002-0314-3467)
Institutions
- University of Copenhagen (DK)
- Aalborg University Hospital (DK)
- Herlev Hospital (DK)
- Bispebjerg Hospital (DK)
- Hvidovre Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Predict (France) (FR)
- Aalborg University (DK)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1093/ibd/izae287
- Citations
- 2
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Celgene
- Gentofte Hospital
- Novo Nordisk
- Aage og Johanne Louis-Hansens Fond
- Tillotts Pharma
- Samsung
- Cilag