Epidemiology and Outcomes of Antibiotic De-escalation in Patients With Suspected Sepsis in US Hospitals
Antibiotic de-escalation in suspected sepsis is infrequent, variable across hospitals, linked with clinical and microbiologic factors, and associated with lower risk for AKI, ICU admission, and in-hospital mortality.
Authors
- Laura DelloStritto
- Sarah Warner (ORCID: https://orcid.org/0000-0002-4998-9257)
- Michael Klompas (ORCID: https://orcid.org/0000-0001-8641-4498)
- David Fram
- Kai‐Qian Kam (ORCID: https://orcid.org/0000-0002-2402-7262)
- Chanu Rhee (ORCID: https://orcid.org/0000-0002-9537-4245)
- Alexander Lawandi (ORCID: https://orcid.org/0000-0001-7948-3161)
- Sameer S. Kadri (ORCID: https://orcid.org/0000-0002-4420-9004)
- Claire Shappell (ORCID: https://orcid.org/0000-0002-8316-1496)
- Huai-Chun Chen
- Morgan Walker (ORCID: https://orcid.org/0000-0002-4699-6777)
- Christina Yek (ORCID: https://orcid.org/0000-0001-8293-3901)
- Tom Chen (ORCID: https://orcid.org/0000-0002-5301-5447)
- Robert Jin
Institutions
- Brigham and Women's Hospital (US)
- McGill University Health Centre (CA)
- Commonwealth Computer Research (United States) (US)
- SingHealth Duke-NUS Academic Medical Centre (SG)
- National Heart, Lung, and Blood Institute (US)
- Harvard Pilgrim Health Care (US)
- KK Women's and Children's Hospital (SG)
- National Institutes of Health Clinical Center (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1093/cid/ciae591
- Citations
- 13
- Primary Topic
- Antibiotic Use and Resistance
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- National Institutes of Health
- Centers for Disease Control and Prevention
- Agency for Healthcare Research and Quality
- National Institute of Allergy and Infectious Diseases
- NIH Clinical Center