ORP5 promotes cardiac hypertrophy by regulating the activation of mTORC1 on lysosome
Our findings provide the inaugural evidence that ORP5 facilitates pathological ventricular hypertrophy through the translocation of mTORC1 to the lysosome for subsequent activation. Consequently, ORP5 has the potential to serve as a diagnostic biomarker or therapeutic target for pathological cardiac hypertrophy in the future.
Authors
- Zhiwen Ding (ORCID: https://orcid.org/0000-0001-9852-3982)
- Jienan Wang
- Di Zhao
- Ran Xu (ORCID: https://orcid.org/0000-0003-1387-6696)
- Xiaoxue Zhang (ORCID: https://orcid.org/0000-0001-7316-0847)
- Jiaying Wu (ORCID: https://orcid.org/0009-0002-3159-9047)
- Yunzeng Zou (ORCID: https://orcid.org/0009-0005-8307-6725)
- Hong Lin
- Yufei Zhou
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1016/j.jare.2024.12.014
- Citations
- 5
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China
- Fudan University
- National Science and Technology Major Project