Characterization of PSA dynamics and oncological outcomes in patients with metastatic hormone-sensitive prostate cancer treated with androgen receptor signaling inhibitors
No significant differences in PSA response was seen between groups; however, distinct optimal cut-offs were demonstrated for PSA nadir and time to nadir. The present findings will be useful for optimal PSA monitoring for mHSPC patients and for early identification of poor-prognosis populations.
Authors
- Tomohisa Matsunaga (ORCID: https://orcid.org/0000-0001-5238-2598)
- Takuya Tsujino (ORCID: https://orcid.org/0000-0003-1559-1889)
- Shinichi Sakamoto (ORCID: https://orcid.org/0000-0002-7508-7521)
- Tomokazu Sazuka (ORCID: https://orcid.org/0000-0002-8902-7853)
- Ryoichi Maenosono (ORCID: https://orcid.org/0000-0002-9045-5484)
- Yuki Yoshikawa (ORCID: https://orcid.org/0000-0001-8834-5051)
- Haruhito Azuma (ORCID: https://orcid.org/0000-0001-5497-1679)
- Atsushi Komaru (ORCID: https://orcid.org/0000-0002-6350-3436)
- Manato Kanesaka
- Kazuki Nishimura (ORCID: https://orcid.org/0000-0002-2878-7664)
- Satoshi Fukasawa (ORCID: https://orcid.org/0000-0002-4759-4999)
- Ko Nakamura (ORCID: https://orcid.org/0000-0002-8734-2147)
- Hiroomi Nakatsu
- Yusuke Imamura (ORCID: https://orcid.org/0009-0006-7207-1520)
- Kazuyoshi Nakamura (ORCID: https://orcid.org/0009-0000-7415-6540)
- Kazumasa Komura (ORCID: https://orcid.org/0000-0003-4157-1929)
- Yasutaka Yamada (ORCID: https://orcid.org/0000-0002-0070-1590)
- Takayuki Arai (ORCID: https://orcid.org/0000-0002-3888-9576)
- Yukio Naya
- Kodai Sato (ORCID: https://orcid.org/0000-0001-6914-4991)
- Maki Nagata
- Kazuto Chiba
- Tatsuo Fukushima (ORCID: https://orcid.org/0009-0002-2823-0628)
- Tomohiko Ichikawa
- Sanae Saito
- Kazuo Mikami
Institutions
- Chiba University (JP)
- Chibaken Saiseikai Narashino Hospital (JP)
- Kin-ikyo Chuo Hospital (JP)
- Chiba Cancer Center (JP)
- Teikyo University Chiba Medical Center (JP)
- Yokohama Rosai Hospital (JP)
- Funabashi Municipal Medical Center (JP)
- Asahi General Hospital (JP)
- Saitama Red Cross Hospital (JP)
- Osaka University of Pharmaceutical Sciences (JP)
Publication Details
- Journal
- International Journal of Clinical Oncology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1007/s10147-024-02676-z
- Citations
- 3
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Uehara Memorial Foundation
- Nippon Shinyaku
- Japan Society for the Promotion of Science London
- Astellas Pharma
- Astellas Foundation for Research on Metabolic Disorders
- Japanese Foundation for Prostate Research
- Japan Society for the Promotion of Science