NRF2 activation in the heart induces glucose metabolic reprogramming and reduces cardiac dysfunction via upregulation of the pentose phosphate pathway
These results indicate that NRF2 regulates cardiac metabolic reprogramming by stimulating the diversion of glucose into the PPP, thereby generating NADPH and providing nucleotides to prevent stress-induced DNA damage and cardiac dysfunction.
Authors
- Anna Zoccarato (ORCID: https://orcid.org/0000-0003-0083-5430)
- Daniel I. Bromage (ORCID: https://orcid.org/0000-0002-4243-5964)
- Greta J. Sawyer (ORCID: https://orcid.org/0000-0003-2801-1900)
- Ioannis Smyrnias (ORCID: https://orcid.org/0000-0001-6422-938X)
- Richard H. Thompson (ORCID: https://orcid.org/0000-0002-7174-7043)
- Anne D. Hafstad (ORCID: https://orcid.org/0000-0003-0711-9736)
- Daniel A. Richards (ORCID: https://orcid.org/0000-0002-9097-9325)
- Christina M. Reumiller (ORCID: https://orcid.org/0000-0001-9072-259X)
- Ajay M. Shah (ORCID: https://orcid.org/0000-0002-6547-0631)
- Xiaohong Zhang (ORCID: https://orcid.org/0000-0002-6732-2499)
- Min Zhang (ORCID: https://orcid.org/0000-0003-1657-1337)
- Sharwari Verma
- Asjad Visnagri (ORCID: https://orcid.org/0000-0003-0191-2629)
- Mei Chong
- Célio X.C. Santos
Institutions
- King's College London (GB)
- University of Surrey (GB)
- British Heart Foundation (GB)
- UiT The Arctic University of Norway (NO)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1093/cvr/cvae250
- Citations
- 22
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 5.14
Funders
- British Heart Foundation
- King's College London
- Fondation Leducq