Decreased urinary excretion of norepinephrine and dopamine in autonomic synucleinopathies
Autonomic synucleinopathies involve decreased urinary excretion rates of norepinephrine and dopamine. Since virtually all of urinary dopamine in humans is derived from circulating DOPA, the low rates of urinary norepinephrine and dopamine excretion may reflect dysfunctions in the renal sympathetic noradrenergic system, the DOPA-dopamine autocrine-paracrine system, or both systems.
Authors
- David S. Goldstein (ORCID: https://orcid.org/0000-0002-5709-9940)
- Courtney Holmes
- Patti Sullivan
Institutions
- National Institutes of Health (US)
- National Institute of Neurological Disorders and Stroke (US)
Publication Details
- Journal
- Clinical Autonomic Research
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1007/s10286-024-01093-6
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- NHLBI Division of Intramural Research