Immunocompetent murine glioblastoma stem-like cell models exhibiting distinct phenotypes
Upon orthotopic implantation in immunocompetent mice, mGSCs generate tumors characteristic of human GBM. Despite similar strategies to generate these mGSCs, they exhibited a range of phenotypes and immune profiles in mGSC-derived orthotopic tumors. These mGSCs provide new preclinical GBM models for developing GBM immunotherapies.
Authors
- Muzammil Arif Din Abdul Jabbar (ORCID: https://orcid.org/0000-0002-4882-8486)
- Hiroaki Wakimoto (ORCID: https://orcid.org/0000-0001-8225-241X)
- Toshiro Hara (ORCID: https://orcid.org/0000-0002-4389-3393)
- Shanawaz M. Ghouse
- Samuel D. Rabkin (ORCID: https://orcid.org/0000-0003-2344-2795)
- Kimia Kardani (ORCID: https://orcid.org/0000-0003-0357-6331)
- Judit Sánchez Gil
- Anat Stemmer‐Rachamimov (ORCID: https://orcid.org/0000-0003-3846-5295)
- Robert L. Martuza
- Yasushi Soda
- Namita Rajasubramanian
Institutions
- Salk Institute for Biological Studies (US)
- Harvard University (US)
- Tokyo Medical University (JP)
- Massachusetts General Hospital (US)
- Center for Cancer Research (US)
- The University of Tokyo (JP)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2024-12-07
- DOI
- https://doi.org/10.1093/noajnl/vdae215
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Cancer Society
- Agency for Science, Technology and Research
- National Institutes of Health
- Harvard Stem Cell Institute