The Primacy of Adipose Tissue Gene Expression and Plasma Lipidome in Cardiometabolic Disease in Persons With HIV
Our multiomic analysis demonstrated coordinated, multitissue molecular reprogramming in virologically suppressed PWH with elevated cardiometabolic disease risk. Longitudinal studies of PWH with assessments of adipose tissue and lipid handling are necessary to understand mechanisms of cardiometabolic disease in PWH. Clinical Trials Registration. NCT04451980.
Authors
- Andrew Perry (ORCID: https://orcid.org/0000-0003-3342-6158)
- Jonathan A. Kropski (ORCID: https://orcid.org/0000-0002-8923-1344)
- J. Jeffrey Carr (ORCID: https://orcid.org/0000-0002-4398-8237)
- Ravi V. Shah (ORCID: https://orcid.org/0000-0002-4471-7156)
- Sangeeta Nair (ORCID: https://orcid.org/0000-0002-9725-9195)
- Samuel Bailin (ORCID: https://orcid.org/0000-0003-4990-1013)
- Heidi J. Silver (ORCID: https://orcid.org/0000-0003-2237-4903)
- Curtis L. Gabriel (ORCID: https://orcid.org/0000-0002-1611-3136)
- Suman R. Das (ORCID: https://orcid.org/0000-0003-2496-9724)
- James Greg Terry (ORCID: https://orcid.org/0000-0001-6659-3441)
- Celestine N. Wanjalla (ORCID: https://orcid.org/0000-0001-9159-5414)
- Siyuan Ma (ORCID: https://orcid.org/0000-0002-1312-6791)
- Jane F. Ferguson (ORCID: https://orcid.org/0000-0001-6896-1025)
- Mona Mashayekhi (ORCID: https://orcid.org/0000-0003-0331-2395)
- Mingjian Shi (ORCID: https://orcid.org/0000-0003-1569-9822)
- John R. Koethe (ORCID: https://orcid.org/0000-0001-6490-6942)
Institutions
- VA Tennessee Valley Healthcare System (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1093/infdis/jiae532
- Citations
- 5
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.45
Funders
- Burroughs Wellcome Fund
- Doris Duke Charitable Foundation
- National Institutes of Health
- National Center for Research Resources