Development of ROS-triggered masked liposomes for activated cellular delivery using a charge balance strategy
We report a charge balance strategy for reactive oxygen species (ROS)-triggered activation of liposome cell delivery by unmasking cationic membranes. Zeta potential experiments, microplate-based vesicle interaction assays, and cellular delivery studies confirmed that modification of anionic lipid 1 by ROS led to the uncaging of cationic liposomes, thereby driving cellular association.
Authors
- Jinchao Lou (ORCID: https://orcid.org/0000-0001-5064-761X)
- Joshua A. Baccile (ORCID: https://orcid.org/0000-0003-4334-755X)
- Michael D. Best (ORCID: https://orcid.org/0000-0001-8737-5910)
- Maria Mustafa (ORCID: https://orcid.org/0000-0001-5554-4978)
- Robert F. Turner
- M. A. Phillips (ORCID: https://orcid.org/0000-0003-2649-5657)
Institutions
- Circle Park (US)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1039/d4cc06309k
- Citations
- 3
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.70