(231) SOLID ORGAN TRANSPLANT IS NOT ASSOCIATED WITH INCREASED COMPLICATION RATES AFTER PENILE PROSTHESIS: A TRINETX STUDY

Abstract Introduction Erectile dysfunction (ED) has increased prevalence among solid organ transplant (SOT) recipients than the general population. Penile prosthesis placement (PPP) allows efficacious treatment, though with concern for increased complications in this population. Here we utilize a large de-identified database to compare complication rates between men who received PPP after SOT and immunosuppression. Objective To determine whether risk of solid organ transplant is associated with an increased risk of penile prosthesis-related complications. Methods Using TriNetX Research Network, we identified men aged ≥18 who underwent PPP and SOT (kidney, lung, heart, liver, intestine, pancreas). Men were grouped into cohorts: patients with PPP excluding transplant status (control), and those with an IPP after SOT. Penile prosthetic-related complications include infection-related, mechanical, thromboembolism, hemorrhage, pain, stenosis, removal without replacement, removal with replacement, and all complications. Kaplan–Meier analysis was performed on the TriNetX platform to compare the occurrence of penile prosthesis complications between cohorts and hazard ratios were calculated. Results 12282 patients were included in the control group and 253 patients were included in the solid organ transplant group. Multiple significant differences were observed in baseline comorbidities including Black or African American race (20% control vs 36% SOT, p < 0.0001), White race (57% vs 38%, p < 0.0001), Hypertensive disorders (52% vs 96%, p < 0.0001), cerebrovascular diseases (7% vs 19%, p < 0.0001), atherosclerosis (5% vs 21%, p < 0.0001), diabetes mellitus (31% vs 79%, p < 0.0001), overweight and obesity (20% vs 44%, p < 0.0001), nicotine dependence (11% vs 23%, p < 0.0001), malignant neoplasms of male genital organs (27% vs 16%, p0.0001), and major depressive disorder (3% vs 8%, p = 0.0002). No statistically significant differences in post-PPP complications were observed in comparison between control and SOT groups including infection-related (HR = 0.56, p = 0.832), mechanical (HR = 0.738,p = 0.95), removal without replacement (HR = 1.033, p = 0.22), removal with replacement (HR = 0.659, p = 0.661) (see Table 2). Thromboembolism, hemorrhage, pain, and stenosis outcomes all had less than 10 instances in the SOT group and could thus not be accurately assessed. Conclusions SOT status itself does not appear be associated with an increased risk of penile prosthesis-related complications when compared to a control population despite increased prevalence of multiple comorbid conditions. Disclosure No.