Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects
Correlation analysis between CSF and plasma oligomer concentrations indicates an impaired clearance of Aβ oligomers that is dependent on the ApoE ε4 status.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Silka Dawn Freiesleben (ORCID: https://orcid.org/0000-0002-2141-8671)
- Jens Wiltfang (ORCID: https://orcid.org/0000-0003-1492-5330)
- Ayda Rostamzadeh (ORCID: https://orcid.org/0000-0001-5189-134X)
- Lukas Preis (ORCID: https://orcid.org/0000-0001-7601-6410)
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Nina Roy
- Oliver Peters (ORCID: https://orcid.org/0000-0003-0568-2998)
- Stefan Johannes Teipel (ORCID: https://orcid.org/0000-0002-3586-3194)
- Michael Ewers (ORCID: https://orcid.org/0000-0003-1856-9337)
- Niels Hansen (ORCID: https://orcid.org/0000-0001-5785-9594)
- Frederic Brosseron (ORCID: https://orcid.org/0000-0003-3137-7516)
- Alfredo Ramı́rez (ORCID: https://orcid.org/0000-0003-4991-763X)
- Matthias Schmid (ORCID: https://orcid.org/0000-0002-0788-0317)
- Boris‐Stephan Rauchmann (ORCID: https://orcid.org/0000-0003-4547-6240)
- Sandra Roeske (ORCID: https://orcid.org/0000-0002-8262-4356)
- Tuyen Bujnicki (ORCID: https://orcid.org/0000-0002-7191-8455)
- Michael Wagner (ORCID: https://orcid.org/0000-0003-2589-6440)
- Anneliese Cousin
- Victoria Kraemer‐Schulien (ORCID: https://orcid.org/0000-0002-7413-7646)
- Katharina Büerger (ORCID: https://orcid.org/0000-0002-5898-9953)
- Klaus Fließbach (ORCID: https://orcid.org/0000-0002-0183-7510)
- Enise I. Incesoy (ORCID: https://orcid.org/0000-0003-2014-4098)
- Josef Priller (ORCID: https://orcid.org/0000-0001-7596-0979)
- Marlene Pils (ORCID: https://orcid.org/0000-0002-1506-3675)
- Oliver Bannach (ORCID: https://orcid.org/0000-0002-7438-3791)
- Frank Jessen (ORCID: https://orcid.org/0000-0003-1067-2102)
- Lara Blömeke (ORCID: https://orcid.org/0000-0002-8861-9224)
- Ingo Kilimann (ORCID: https://orcid.org/0000-0002-3269-4452)
- Anja Schneider (ORCID: https://orcid.org/0000-0001-9540-8700)
- Fabian Rehn (ORCID: https://orcid.org/0000-0001-8815-0684)
- Michael T. Heneka (ORCID: https://orcid.org/0000-0003-4996-1630)
- Slawek Altenstein (ORCID: https://orcid.org/0000-0003-2753-5999)
- Luisa‐Sophie Schneider (ORCID: https://orcid.org/0000-0001-5822-1744)
- Janine Kutzsche (ORCID: https://orcid.org/0000-0003-0271-7390)
- Wenzel Glanz (ORCID: https://orcid.org/0000-0002-5865-4176)
- Matthias H. Munk (ORCID: https://orcid.org/0000-0002-5339-4045)
- Eike Spruth
- Dieter Willbold (ORCID: https://orcid.org/0000-0002-0065-7366)
- Christoph Laske
Institutions
- University of Bonn (DE)
- Forschungszentrum Jülich (DE)
- University of Cologne (DE)
- University of Luxembourg (LU)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Humboldt-Universität zu Berlin (DE)
- Institute for Neurodegenerative Disorders (US)
- Munich Cluster for Systems Neurology (DE)
- UK Dementia Research Institute (GB)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Magdeburg (DE)
- Hertie Institute for Clinical Brain Research (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Rostock (DE)
- Imperial College London (GB)
- University of Aveiro (PT)
- Technical University of Munich (DE)
- University of Göttingen (DE)
- Hochschule Düsseldorf University of Applied Sciences (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Sheffield (GB)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1038/s43856-024-00690-w
- Citations
- 7
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Forschungszentrum Jülich
- Helmholtz Association