Integrated molecular characterization of sarcomatoid hepatocellular carcinoma
We offer a comprehensive description of the molecular basis for sarcomatoid HCC, and identify genomic alteration (ARID2 mutation) together with the tumor microenvironment (hypoxic microenvironment), that may contribute to the formation of the sarcomatoid tumor component through EMT, leading to sarcomatoid HCC development and progression.
Authors
- Jing-Yue Pan
- Shao‐Lai Zhou (ORCID: https://orcid.org/0000-0002-8526-5221)
- Zhiqiang Hu (ORCID: https://orcid.org/0000-0003-0806-7616)
- Yu-Hang Ye
- Ye Xu (ORCID: https://orcid.org/0000-0001-8052-9147)
- Si-Yuan Pan (ORCID: https://orcid.org/0000-0002-0128-3001)
- Rongqi Sun
- Long Chen (ORCID: https://orcid.org/0000-0002-2979-5033)
- Ning Li (ORCID: https://orcid.org/0000-0001-8650-8603)
- Bo Wang (ORCID: https://orcid.org/0000-0002-9027-4077)
- Jia Fan
- Zheng‐Jun Zhou (ORCID: https://orcid.org/0000-0003-4875-6838)
- Chengli Song (ORCID: https://orcid.org/0000-0002-2023-9700)
- Jian Zhou (ORCID: https://orcid.org/0000-0003-4166-2564)
Institutions
- Sun Yat-sen University (CN)
- Dalian Medical University (CN)
- Fudan University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.3350/cmh.2024.0686
- Citations
- 5
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China