WWP1 inhibition suppresses the proliferation of pancreatic cancer cells by regulating the PI3K-AKT pathway
WWP1 inhibition enhances the anti-tumor effects of PI3K-AKT pathway inhibitors through PTEN activation. Thus, WWP1 could be a potential therapeutic target in PDAC.
Authors
- Kengo Yasugi (ORCID: https://orcid.org/0000-0003-0106-7912)
- Takahiro Seimiya (ORCID: https://orcid.org/0000-0003-1698-0309)
- Keisuke Yamamoto (ORCID: https://orcid.org/0000-0002-6323-9540)
- Takahiro Kishikawa (ORCID: https://orcid.org/0000-0002-8602-5916)
- Hideaki Ijichi (ORCID: https://orcid.org/0000-0002-2379-7986)
- Genso Notoya (ORCID: https://orcid.org/0009-0007-0769-1528)
- Mitsuhiro Fujishiro (ORCID: https://orcid.org/0000-0002-4074-1140)
- Motoyuki Otsuka (ORCID: https://orcid.org/0000-0003-2869-2881)
- Koji Miyabayashi (ORCID: https://orcid.org/0000-0002-4588-2575)
- Takuma Iwata (ORCID: https://orcid.org/0000-0001-5229-3042)
- Ryota Takahashi (ORCID: https://orcid.org/0000-0001-7886-8481)
Institutions
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of Gastroenterology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1007/s00535-024-02192-x
- Citations
- 1
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- University of Tokyo
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Kobayashi Foundation for Cancer Research