GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in metabolic dysfunction-associated steatohepatitis livers
In MASH livers, upregulation of GOLM1 by IL-1β increases ABCG5-mediated cholesterol efflux in an OPN-dependent manner, promoting CGS formation. GOLM1 has the potential to be a molecular hub interconnecting MASH and CGSs.
Authors
- Jing Lin (ORCID: https://orcid.org/0000-0002-8845-2719)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-6546-8443)
- Baorui Tao (ORCID: https://orcid.org/0000-0002-5103-402X)
- Chenhe Yi (ORCID: https://orcid.org/0000-0003-0809-7196)
- Zhenmei Chen
- Jinhong Chen (ORCID: https://orcid.org/0000-0003-0952-9990)
- Guo Zhang (ORCID: https://orcid.org/0000-0002-3880-6996)
- Yitong Li (ORCID: https://orcid.org/0000-0003-3402-4484)
- Yue Ma (ORCID: https://orcid.org/0000-0003-4418-5249)
- Rui Zhang (ORCID: https://orcid.org/0000-0001-9000-5021)
- Xiaochen Ma (ORCID: https://orcid.org/0000-0002-4931-2019)
- Weiqing Shao
- Yan Geng (ORCID: https://orcid.org/0000-0001-6852-8395)
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.3350/cmh.2024.0657
- Citations
- 12
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.87
Funders
- National Natural Science Foundation of China
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund