(242) THE IMPACT OF ENVIRONMENTAL FACTORS AND CHRONIC MEDICAL CONDITIONS ON SEMEN PARAMETERS: A TEN-YEAR LONGITUDINAL ANALYSIS

Abstract Introduction The environmental and chronic medical conditions including metabolic risk factors appear to continue to negatively impact the semen qualities in men worldwide including United States. Poor semen parameters is often used as marker for underlying men’s health and can be associated with increased morbidities and overall mortality. Objective In this large longitudinal analysis, we aim to evaluate the correlations between variable risk factors and medical conditions and semen analysis in adult men at a large reproductive urology center. Methods In this ten-year retrospective chart review, male patients ≥18 of age with documented semen analyses were included. Data collected included the patients’ demographics, comorbid medical conditions recreational alcohol, tobacco or marijuana use. Semen analysis as per WHO 10th reference included sperm concentration, count and motility. Data analyzed using multivariate and univariate linear regression and logistic regression. Results A total of 2,322 patients were included in the study. White and black non-Hispanic men had higher rates of oligospermia and/or azoospermia compared with Asian men (p < 0.001) and had higher body mass index (BMI) (p = 0.019). Among the comorbidities, type 2 diabetes (p = 0.046), hypertension (p = 0.014), anemia (p = 0.001), chronic kidney disease (p = 0.013), and heart failure (p = 0.001) were associated with higher rates of oligospermia and/or azoospermia. Among recreational use, tobacco and marijuana use were associated with oligospermia. (p = 0.043) (Table 1). Conclusions In our study, environmental and metabolic risk factors and conditions appear to be significantly associated with reduced semen qualities particularly sperm concentration, count and motility. This analysis underpins this critical association between men’s health marker ie, semen analysis and underlying environmental and chronic medical conditions in men at-risk. Future studies are warranted to further exploit these association and provide appropriate medical counseling and treatment. Disclosure No.