Key β1-4 galactosylated glycan receptors of SARS-CoV-2 and its inhibitor from the galactosylated glycoproteins of bovine milk
Our findings demonstrated that the β1-4 galactosylated N-glycans of ACE2 play a crucial role as glycan receptors for the binding of S1 of SARS-CoV-2 and its variations. Moreover, the glycoproteins with 'receptor-like' glycoforms could be an effective inhibitor to prevent SARS-CoV-2 infection.
Authors
- Hanjie Yu (ORCID: https://orcid.org/0000-0003-2684-8715)
- Hongwei Cheng (ORCID: https://orcid.org/0000-0003-1403-6752)
- Jian Hong Shu (ORCID: https://orcid.org/0000-0002-2938-4218)
- Xiaojuan Bao
- Wentian Chen
- Xilong Wang (ORCID: https://orcid.org/0009-0001-1914-7665)
- Zheng Li
- Jia Quan
- Xin Wu
- Di Wu Resource
Institutions
- Northwest University (CN)
- Wuhan Institute of Virology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1016/j.jare.2024.12.010
- Citations
- 1
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shaanxi Province
- Postdoctoral Research Foundation of China
- Key Research and Development Projects of Shaanxi Province