Unraveling morphine tolerance: CCL2 induces spinal cord apoptosis via inhibition of Nrf2 signaling pathway and PGC-1α-mediated mitochondrial biogenesis
Our data emphasize that chemokine CCL2 inhibited the Nrf2 signaling pathway and PGC-1α-mediated mitochondrial biogenesis, alleviating the occurrence of apoptosis in spinal cord, thereby participating in morphine tolerance. This may provide new targets for the treatment of morphine tolerance.
Authors
- Wei Zhao (ORCID: https://orcid.org/0000-0001-5698-4844)
- Jie Ju (ORCID: https://orcid.org/0000-0001-8931-3270)
- Zheng Li (ORCID: https://orcid.org/0000-0001-8067-9700)
- Jie Liu (ORCID: https://orcid.org/0000-0001-6988-5773)
- Feng Gao (ORCID: https://orcid.org/0000-0001-7115-665X)
- Jihao Ren
- Peng Xiaoling
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.bbi.2024.12.011
- Citations
- 6
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- National Natural Science Foundation of China