Higher risk profile among patients with TET2-mutated giant cell arteritis: a cluster analysis
CH is prevalent among patients with GCA but does not differ significantly from controls or other autoimmune conditions. However, specific genetic profiles, particularly mutations in TET2 and JAK2, are associated with a higher risk cluster within the GCA cohort. This observation highlights the interest of detecting CH in patients with GCA in both routine practice and clinical trials for better risk stratification. Further prospective studies are needed to determine if management tailored to the genetic profile would improve outcomes.
Authors
- Julien Rossignol (ORCID: https://orcid.org/0000-0003-3052-1424)
- Nabil Belfeki (ORCID: https://orcid.org/0000-0002-9736-6732)
- N. Ghriss
- Éric Solary (ORCID: https://orcid.org/0000-0002-8629-1341)
- Olivier Espitia (ORCID: https://orcid.org/0000-0003-0821-9990)
- Alexis F. Guédon (ORCID: https://orcid.org/0000-0002-4571-6219)
- Azeddine Dellal
- O. Fain (ORCID: https://orcid.org/0000-0002-1974-3870)
- Jean‐Yves Scoazec (ORCID: https://orcid.org/0000-0003-1604-6823)
- Fadi Haidar (ORCID: https://orcid.org/0000-0002-8133-1105)
- Christophe Marzac (ORCID: https://orcid.org/0000-0001-5065-0376)
- Marc Scheen (ORCID: https://orcid.org/0000-0003-2661-3000)
- Olivier Hermine (ORCID: https://orcid.org/0000-0003-2574-3874)
- A. Mékinian (ORCID: https://orcid.org/0000-0003-2849-3049)
- Asmaa Ouafdi
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Gustave Roussy (FR)
- Sorbonne Université (FR)
- Institut Necker Enfants Malades (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Saint-Antoine (FR)
- Melun Hospital (FR)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
- Institut du Thorax (FR)
- Groupe Hospitalier Intercommunal Le Raincy Montfermeil (FR)
- Institut des Maladies Génétiques Imagine (FR)
- Nantes Université (FR)
Publication Details
- Journal
- RMD Open
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/rmdopen-2024-004694
- Citations
- 2
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.84