(266) UNDIAGNOSED CARDIAC RISK FACTORS ARE HIGHLY PREVALENT IN YOUNG MEN PRESENTING WITH INFERTILITY

Abstract Introduction Male Fertility is a marker of overall health. The relationship between cardiovascular risk factors (CVR) and male infertility is an emerging area of interest with prior data showing the incidence of developing cardiac disease over time being greater in men with male factor infertility versus the general population. Objective Our study sought to determine the prevalence of CVR factors among young men presenting for infertility evaluation at an Andrology Clinic. Methods A retrospective review was conducted on all patients (pts) under the age of 45 years who presented to an infertility clinic between March 2023 and May 2024. Patient demographics, smoking status, comorbidities, Lipid panel ([triglycerides (TG), cholesterol (Chol), low-density lipoproteins (LDL), high-density lipoproteins (HDL)]), Body Mass Index (BMI), blood pressure (BP), and a complete hormone panel were collected. The hormone panel included free testosterone (fT), total testosterone (TT), estradiol (E2), sex hormone binding globulin (SHBG), prolactin (P), follicle-stimulating hormone (FSH), luteinizing hormone (LH), Hemoglobin A1c (HgA1c), and hematocrit (Hct). The hormonal panel was collected before 11 AM using LCMS. Individuals with any missing values were not included in the analyses. Results 442 men with a mean age of 28.03 years [sd 7.02] were included. The mean BMI was 28.04 kg/m2 [sd 7.02]. In this cohort, only 4.4% of patients had a prior diagnosis of Diabetes Mellitus (DM), 9.4% with Hypertension (HTN), and 5.5% with dyslipidemia (DLP). However, among new pts presenting for infertility evaluation without any known comorbidities 22.0% of pts had elevated HbA1c ≥5.7%, 61.78% had HTN (>120/80 mmHg) on two consecutive reads, 31.5% had elevated TG levels (≥150 mg/dL), 35.0% had low HDL levels (<40 mg/dL), and 38.23% of pts had two or more of these risk factors. 36.6% percent of pts were overweight (BMI ≥25 and < 30 kg/m2), 17.6% were obese (BMI ≥30 and < 35 kg/m2), and 11.2% were morbidly obese (BMI ≥35 kg/m2). 26.0% of pts were smokers, and 21.9% had hypogonadism (TT <300 ng/dL). There was no statistically significant difference in the prevalence of these risk factors among different ethnic groups or ages. Conclusions Our study revealed a high prevalence of undiagnosed CVR factors in young men presenting for primary infertility evaluation. Our study underscores urologists' pivotal role in evaluating overall men’s health. Assessing BMI, BP measurements, HgA1c, lipid, and hormone panels in this patient population may be useful parameters to identify young infertile men at risk for cardiac disease and lead to earlier detection of undiagnosed CVR factors and early preventative interventions. Disclosure Any of the authors act as a consultant, employee or shareholder of an industry for: Boston Scientific; Coloplast; BK Ultrasound.