(305) MEN WITH PEYRONIE’S DISEASE ARE DIAGNOSED WITH CANCER AT AN EARLIER AGE: GENETICS OR A FOOT IN THE DOOR?

Abstract Introduction Men with Peyronie’s Disease (PD) are theorized to have an increased cancer risk. PD is characterized by infiltrative growth, proliferation, and decreased apoptosis- pathways shared by malignant neoplastic growth. Thus, one can hypothesize a genetic predisposition toward cancer as heralded by PD pathogenesis. Objective To investigate this hypothesis, we identified patients with and without PD over a 28-year period and quantified demographics and cancer incidences. Methods We performed a retrospective review of patients cared for by a single urologic provider in Houston, Texas, from 1995 to 2023 and identified those patients with and without PD. These data were sent to the Texas Cancer Registry who identified those patients with a diagnosis of cancer. They returned data including age at diagnosis, cancer anatomic site, and histologic subtype. Data were then studied in detail, and appropriate statistical analyses performed with GraphPad Prism Software. Results From 1995-2023 we identified 148 patients with PD and a diagnosis of cancer and 707 patients without PD (controls) and a diagnosis of cancer. Overall, patients with PD were diagnosed at an earlier age across all cancers v. controls (median 59 y v 64 y, p = 0.0008, student’s t-test). The relative frequencies of cancer subtypes were then compared between the PD and control group and log transformed. Overall, we found higher relative frequencies (2-fold difference) of nervous system, ill-defined, intrahepatic bile duct, nasal cavity, oropharynx, and thyroid cancers and lower relative frequencies of kidney, large intestine, and renal pelvis/ureter cancers in the PD group. Regarding histologic subtypes in this cohort, we found higher relative frequencies of bile duct adenocarcinoma, follicular lymphoma, intraductal papillary-mucinous carcinoma, Kaposi sarcoma, and melanoma, and lower relative frequencies of carcinoid, clear cell adenocarcinoma, multiple myeloma, and unspecified neoplasms. Conclusions Patients with PD are diagnosed with cancer at an earlier age. Our data aligns with previous work demonstrating higher rates of upper aerodigestive tract and melanoma cancers and lower rates of large intestine and kidney cancers in men with PD. We provide a more detailed and stratified look among histologic cancer subtypes within men with PD. While our data support the genetic similarity hypothesis in which PD and malignant neoplasm share pathologic pathways, it also raises the question of whether PD simply brings patients to the doctor’s office sooner, resulting in increased cancer detection and diagnosis. Disclosure No.