The Expression of HIF-1α and VEGF in Radicular Cysts and Periapical Granulomas
There is high expression of both HIF-1α and VEGF throughout the odontogenic epithelium and connective tissue of the radicular cyst and periapical granuloma. Both HIF-1α and VEGF are more highly expressed in radicular cysts than in periapical granulomas. These findings may aid in the diagnosis and management of suspected periapical lesions, suggesting that radicular cysts exhibit more advanced hypoxic conditions and associated pathways compared with periapical granulomas.
Authors
- Shishir Shetty (ORCID: https://orcid.org/0000-0002-8097-6024)
- Sudhir Varma (ORCID: https://orcid.org/0000-0001-6793-9344)
- Mohammed Amjed Alsaegh (ORCID: https://orcid.org/0000-0003-1986-0855)
- Alaa Muayad Altaie (ORCID: https://orcid.org/0000-0002-2301-0899)
- Okba Mahmoud (ORCID: https://orcid.org/0000-0002-3355-1429)
- Surendra Singh Rawat (ORCID: https://orcid.org/0000-0002-7414-5865)
Institutions
- Ajman University (AE)
- University of Sharjah (AE)
- Mohammed Bin Rashid University of Medicine and Health Sciences (AE)
Publication Details
- Journal
- European Journal of Dentistry
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1055/s-0044-1795078
- Citations
- 2
- Primary Topic
- Oral and Maxillofacial Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- University of Sharjah