(280) NO DIFFERENCE IN PENILE PROSTHESIS COMPLICATION RATE BETWEEN ESRD AND RENAL TRANSPLANT RECIPIENTS: A TRINETX COHORT STUDY

Abstract Introduction Erectile dysfunction (ED) is estimated to have 54-66% prevalence among renal transplant recipients. Patients with end-stage renal disease (ESRD) are known to be at significant risk of perioperative complications. However, in men with ESRD, it is unclear whether penile implantation while on dialysis has a benefit over implantation after transplantation. We utilize a large de-identified database to compare complication rates between patients with ESRD and renal transplant recipients. Objective To determine whether there is a difference in penile prosthesis complications between patients dependent on dialysis and patients who have received a kidney transplant. Methods Using TriNetX Research Network, we identified patients with history of renal transplant, ESRD, or dialysis-dependent status preceding PPP utilizing ICD-10 and CPT codes. Patients were then grouped into a renal transplant or ESRD/dialysis-dependent status cohort. Penile prosthetic-related complications include infection-related, mechanical, thromboembolism, hemorrhage, pain, stenosis, removal without replacement, removal with replacement, and all complications. Kaplan–Meier analysis was performed on the TriNetX platform to compare occurrence of penile prosthesis complications between cohorts and hazard ratios were calculated. Results 168 and 196 patients were retrieved with median follow up time of 1265 and 1007 days in renal transplant and on dialysis cohorts, respectively. Significant baseline characteristic differences included American Indian/Alaska Native (p = 0.0005) with <6% and 0% in the renal transplant group and dialysis-dependent group respectively and Hypertensive diseases (p = 0.006) with 96% and 89% in the renal transplant group and dialysis-dependent group respectively. No significant differences in post-PPP complications were observed in hazard ratios including all outcomes (HR 1.216, p = 0.154), infection-related (HR 1.068, p = 0.864), mechanical (HR 0.836, p = 0.513), removal without replacement (HR 1.381, p = 0.7385), and removal with replacement (HR 1.269, p = 0.2235). Less than 10 patients in either group were found to have outcomes including thromboembolism, hemorrhage, pain, and stenosis so these outcomes could not be accurately assessed. Less than 10 patients in the dialysis-dependent group were found to have removal without replacement. Conclusions The risk of penile prosthesis complications does not appear to differ between men with previous renal transplant compared to men dependent on dialysis. Disclosure No.