Design, synthesis of N-thianyl indole acetamide derivatives as potential plant growth regulator

The design, synthesis, and testing of acetamide derivatives C containing indole structures were carried out to determine their potential for regulating plant growth. The root growth of Arabidopsis thaliana was strongly inhibited by certain compounds, with compounds C2 , C4 , C6 , and C7 achieving a 100 % inhibitory rate at a concentration of 100 µM. The growth of lateral roots in A. thaliana was significantly promoted by compounds C2 and C6 at a concentration of 50 µM. Additionally, these compounds have been found to increase the expression of genes associated with lateral root development, including IAA14 , LAX3 , AXR3 , GH3.1 , GH3.3 , and BRU6 . These genes are involved in the auxin signaling pathway and IAA-amino synthase-related genes. In brief, these target compounds may be promising lead compounds for developing agents that can regulate plant growth.