Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome
This study identified PlGF as a significant contributor to the exacerbation of HPS associated with cirrhosis, through its regulation of pulmonary nitric oxide production. Our findings demonstrated that PlGF deficiency mitigates the severity of both cirrhosis and HPS in the CBDL model, highlighting its potential as a therapeutic target in cirrhosis-induced HPS. Notably, this protective effect was absent in the PPVL model, which induces HPS associated with portal hypertension without cirrhosis. These results open avenues for novel pharmacological interventions aiming to improve outcomes for patients with cirrhosis-induced HPS.
Authors
- Mina Ottaviani
- Emmanuel M. Gonzales (ORCID: https://orcid.org/0000-0002-1546-3193)
- Mina Ha (ORCID: https://orcid.org/0000-0003-1011-9446)
- Frédéric Di Fiore (ORCID: https://orcid.org/0000-0001-7955-6594)
- F. Robert (ORCID: https://orcid.org/0000-0003-3132-8706)
- Florent Dumont (ORCID: https://orcid.org/0000-0002-4439-5070)
- Christophe Guignabert (ORCID: https://orcid.org/0000-0002-8545-4452)
- Frederic Guinut
- Ly Tu (ORCID: https://orcid.org/0000-0003-2336-5099)
- Audrey Coilly (ORCID: https://orcid.org/0000-0003-3149-8617)
- Laurent Savale (ORCID: https://orcid.org/0000-0002-6862-8975)
- Raphaël Thuillet (ORCID: https://orcid.org/0000-0002-1379-3797)
- Marc Humbert (ORCID: https://orcid.org/0000-0003-0703-2892)
- Céline Verstuyft (ORCID: https://orcid.org/0000-0002-8534-224X)
- Olivier Sitbon (ORCID: https://orcid.org/0000-0002-1942-1951)
- Alessandra Cuomo (ORCID: https://orcid.org/0000-0002-5781-2865)
- Corinne Normand
- Feriel Benchenouf
- Maxime Surbier
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Aix-Marseille Université (FR)
- Université Paris-Saclay (FR)
- Janssen (France) (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hypertension pulmonaire : physiopathologie et innovation thérapeutique (FR)
- Federico II University Hospital (IT)
- Centre d’Immunologie de Marseille-Luminy (FR)
- Bicêtre Hospital (FR)
- Hôpital Paul-Brousse (FR)
- Centre d'Immunophénomique
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101297
- Citations
- 3
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Fondation du Souffle
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Chancellerie des Universités de Paris