Static Versus Dynamic Model Predictions of Competitive Inhibitory Metabolic Drug–Drug Interactions via Cytochromes P450: One Step Forward and Two Steps Backwards
Static models are not equivalent to dynamic models for predicting metabolic DDIs via competitive CYP inhibition across diverse drug parameter spaces, particularly for vulnerable patients. Caution is warranted in drug development if static IVIVE approaches are used alone to evaluate metabolic DDI risks.
Authors
- Aki T. Heikkinen (ORCID: https://orcid.org/0000-0002-1923-8153)
- Masoud Jamei (ORCID: https://orcid.org/0000-0002-3443-0194)
- Thomas M. Polasek (ORCID: https://orcid.org/0000-0003-1008-5223)
- Amin Rostami‐Hodjegan (ORCID: https://orcid.org/0000-0003-3917-844X)
- Anthonia Onasanwo
- Iain Gardner (ORCID: https://orcid.org/0000-0002-4811-8513)
- Ivan Tiryannik
Institutions
- Manchester Royal Infirmary (GB)
- University of Manchester (GB)
- Research and Studies Telecommunications Centre (TN)
- Monash University (AU)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1007/s40262-024-01457-1
- Citations
- 8
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.73