The N6-methyladenosine demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification
This study showed that ALKBH5 attenuated aortic valve calcification through the TGFBR2/SMAD2 signalling pathway via direct m6A modification of TGFBR2.
Authors
- Shengping He (ORCID: https://orcid.org/0000-0003-4245-357X)
- Xiaodong Fu (ORCID: https://orcid.org/0000-0003-2754-8976)
- Dongxing Zhu (ORCID: https://orcid.org/0000-0001-5419-438X)
- Hongjiao Yu (ORCID: https://orcid.org/0000-0001-7349-461X)
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Huan Zhao (ORCID: https://orcid.org/0000-0002-7859-3681)
- Kun Li (ORCID: https://orcid.org/0000-0002-2755-8149)
- Vicky Elizabeth MacRae (ORCID: https://orcid.org/0000-0001-6306-7040)
- Yuan Liang (ORCID: https://orcid.org/0000-0002-1861-4479)
- Guojun Chen
- Yuchen Xie (ORCID: https://orcid.org/0009-0008-0891-9288)
- Yueheng Wang (ORCID: https://orcid.org/0009-0005-5138-3376)
- Guoli Zhong (ORCID: https://orcid.org/0009-0009-3801-5391)
- Lan Lan (ORCID: https://orcid.org/0000-0002-8425-9321)
Institutions
- Roslin Institute (GB)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Nanfang Hospital (CN)
- Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Anglia Ruskin University (GB)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
- University of Edinburgh (GB)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1093/cvr/cvae253
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province