The Frequency and Incidence of QT Prolongation With Extended Use of Bedaquiline or Delamanid in a Large, Multi-Country Multidrug-Resistant/Rifampicin-Resistant Tuberculosis Cohort
We demonstrate that Bdq and/or Dlm use beyond 6 months is safe in longer MDR/RR-TB regimens with most clinically relevant QT prolongation events occurring in the first 6 months. Electrocardiogram (ECG) monitoring for early identification of QT prolongating events is possible in programmatic conditions.
Authors
- Nana Kiria (ORCID: https://orcid.org/0000-0002-7449-3296)
- Palwasha Khan (ORCID: https://orcid.org/0000-0002-0873-8355)
- Uzma Khan (ORCID: https://orcid.org/0000-0002-3602-5950)
- Cecilio L Tan
- Edwin H. Herrera-Flores (ORCID: https://orcid.org/0000-0001-8869-4403)
- Shahid Mamsa
- Helena Huerga (ORCID: https://orcid.org/0000-0003-0302-9063)
- Nathalie Lachenal
- Jamil Faqirzai
- Mathieu Bastard (ORCID: https://orcid.org/0000-0002-4296-8867)
- Razia Fatima (ORCID: https://orcid.org/0000-0002-2340-6121)
- Fauziah Asnely Putri
- Jude Beauchamp
- Nara Melikyan (ORCID: https://orcid.org/0000-0001-5303-8609)
- Carole Diane Mitnick (ORCID: https://orcid.org/0000-0002-3455-658X)
- Catherine Hewison (ORCID: https://orcid.org/0000-0002-0363-1479)
- Michael Rich (ORCID: https://orcid.org/0000-0003-4333-4695)
- Muhammad Rafi Siddiqui
- Munira Khan (ORCID: https://orcid.org/0000-0003-2083-2106)
- Afshan K. Isani
- Cut Yulia Indah Sari
- Ye Yint Naing
- Molly Forrest Franke (ORCID: https://orcid.org/0000-0002-4890-5728)
- Yerkebulan Algozhin
- Stalz Charles Vilbrun (ORCID: https://orcid.org/0009-0002-9482-1725)
- Francis Varaine
- Luan Nguyen Quang Vo (ORCID: https://orcid.org/0000-0002-5937-6286)
- Saki Nagashima
- Shirajul Islam
- Saman Ahmed
- Amsalu Bekele
- Kwonjune J. Seung (ORCID: https://orcid.org/0000-0003-0417-4625)
- Patrick Nkunkanyirazo
Institutions
- Brigham and Women's Hospital (US)
- Partners In Health (US)
- Médecins Sans Frontières (UG)
- Harvard University (US)
- National University Bangladesh (BD)
- Sindh Institute of Urology and Transplantation (PK)
- Indus Hospital (PK)
- Health Net (US)
- Karolinska Institutet (SE)
- London School of Hygiene & Tropical Medicine (GB)
- Hospital Nacional Cayetano Heredia (PE)
- Epicentre (South Africa) (ZA)
- Relief International (US)
- Médecins Sans Frontières (GB)
- Médecins Sans Frontières (CH)
- Gheskio Centers (HT)
- National University of Technology (PK)
- Directorate General of Health Services (BD)
- Universitas Islam Jakarta (ID)
- Médecins Sans Frontières (US)
- Interactive Research and Development (PK)
- Harvard Global Health Institute (US)
- Addis Ababa University (ET)
- McGill University (CA)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1093/cid/ciae601
- Citations
- 6
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.33