Experimental induction of anti-muscarinic type-3-receptor extracellular loop antibodies by immunization with 4-hydroxy-2-nonenal modified Ro60 and unmodified Ro60
Our data show induction of increasing anti-M3R antibodies in rabbits immunized with Ro60/HNE-Ro60 or Ro60 peptides and differential induction of these antibodies in mice immunized with Ro60 modified with increasing HNE. These findings suggest that M3R ECL2/ECL3 are involved in SjD autoimmunity progression.
Authors
- Martha Tsaliki
- R. Hal Scofield (ORCID: https://orcid.org/0000-0003-1015-5850)
- Biji T. Kurien (ORCID: https://orcid.org/0000-0002-7877-6859)
- Valerie M Lewis
- D. Dave (ORCID: https://orcid.org/0000-0002-8334-2158)
- Syed M. Quadri (ORCID: https://orcid.org/0000-0002-6395-7542)
Institutions
- Oklahoma Medical Research Foundation (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Clinical & Experimental Immunology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1093/cei/uxae114
- Citations
- 1
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Alexander S. Onassis Public Benefit Foundation
- National Institutes of Health