<i>Plasmodium knowlesi</i> Infection Is Associated With Elevated Circulating Biomarkers of Brain Injury and Endothelial Activation
Our findings highlight for the first time a potential impact of P knowlesi infection on the brain, with specific changes in cerebral injury and endothelial activation biomarker profiles. Further studies are warranted to investigate the pathophysiology and clinical significance of these altered markers, through neuroimaging and long-term neurocognitive assessments.
Authors
- Samuel C. Wassmer (ORCID: https://orcid.org/0000-0002-6753-3376)
- Meng Yee Lai (ORCID: https://orcid.org/0000-0002-4544-695X)
- Cesc Bertran-Cobo (ORCID: https://orcid.org/0000-0001-9286-9595)
- Elin Dumont
- Naqib Rafieqin Noordin (ORCID: https://orcid.org/0000-0001-8462-9831)
- Kevin K. A. Tetteh (ORCID: https://orcid.org/0000-0003-2733-0037)
- Yee Ling Lau (ORCID: https://orcid.org/0000-0002-2037-2165)
- Sanjeev Krishna (ORCID: https://orcid.org/0000-0003-0066-0634)
- William J. Stone (ORCID: https://orcid.org/0000-0002-6647-0166)
- Chris Drakeley
Institutions
- University of London (GB)
- University of Cape Town (ZA)
- St George's, University of London (GB)
- University of Malaya (MY)
- London School of Hygiene & Tropical Medicine (GB)
- Centre de Recherche Médicales de Lambaréné (GA)
- Neuroscience Institute (IT)
- University of Tübingen (DE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1093/infdis/jiae553
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- London School of Hygiene and Tropical Medicine
- National Institutes of Health
- Medical Research Council
- National Institute of Allergy and Infectious Diseases