CD36 deficiency

A 46-year-old man with a 5-year history of hypertension presented to the cardiology department with a 1-month history of dyspnea.His family history was unremarkable.Although his vital signs were stable, physical examination showed S3 gallop and leg edema.Laboratory studies revealed elevated levels of serum creatinine (2.31 mg/dl), N-terminal pro-brain natriuretic peptide Figure 1.Cardiac scintigraphy showing (A) preserved myocardial perfusion (Thallium-201), but (B) a total defect of myocardial fatty acid uptake (arrows).(C) Flow cytometry revealing a deficiency in cluster of differentiation (CD) 36 expression in monocytes.