The fruit fly Drosophila melanogaster as a screening model for antiseizure medications
Our results show that particularly sodium channel blockers as well as valproate are effective in suppressing seizure activity in the bang-sensitive mutant <i>eas</i> <sup><i>2F</i></sup> . These findings demonstrate the usability of <i>Drosophila</i> for screening drugs with antiseizure properties. Due to fewer ethical concerns, the short life cycle, and low maintenance costs, <i>Drosophila</i> might provide an attractive and innovative high-throughput model for the discovery of novel antiseizure compounds.
Authors
- Henner Koch (ORCID: https://orcid.org/0000-0002-6883-3071)
- Florian P. Fischer (ORCID: https://orcid.org/0009-0006-4236-8403)
- Robin A. Karge
- Stefan Wolking (ORCID: https://orcid.org/0000-0002-1460-6623)
- Aaron Voigt (ORCID: https://orcid.org/0000-0002-0428-7462)
- Yvonne Weber (ORCID: https://orcid.org/0000-0002-0806-5592)
Institutions
- Forschungszentrum Jülich (DE)
- Jülich Aachen Research Alliance (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.3389/fphar.2024.1489888
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung