Methodological and reporting recommendations for clinical trials in Nutritional Psychiatry: Guidelines from the International Society for Nutritional Psychiatry Research
Research on nutraceutical and dietary interventions in psychiatry has grown substantially, but progress is hindered by methodological inconsistencies and limited reporting standards. To address this, the International Society for Nutritional Psychiatry Research presents the first guidelines on clinical trial design, conduct, and reporting for future clinical trials in this area. Recommendations were developed using a Delphi process including eighteen researchers with considerable clinical trial expertise and experience in either methodology, nutraceutical, or dietary interventions in psychiatry. These guidelines provide forty-nine recommendations for clinical trial design and outcomes, five for trial reporting, and seven for future research priorities. The recommendations included in these guidelines are designed to inform both nutraceutical and dietary clinical trial interventions in Nutritional Psychiatry. Common themes include an emphasis on the importance of a multidisciplinary research team and integration of co-design processes into the conduct and design of clinical research, methods to improve transparency and replicability of trial outcomes, and measures to address common biases in nutrition trials. Furthermore, we provide recommendations for future research including examining a greater variety of nutraceutical and dietary interventions, scalable delivery models, effectiveness and implementation studies, and the need to investigate these interventions in the prevention and management of less studied psychiatric conditions (e.g. schizophrenia and bipolar disorder). Recommendations included within these guidelines are intended to improve the rigor and clinical relevance of ongoing and future clinical trials in Nutritional Psychiatry.
Authors
- Scott B. Teasdale (ORCID: https://orcid.org/0000-0001-6769-8421)
- Adrian L. Lopresti (ORCID: https://orcid.org/0000-0002-6409-7839)
- Heather Francis (ORCID: https://orcid.org/0000-0002-7223-7782)
- Heidi M. Staudacher (ORCID: https://orcid.org/0000-0001-6704-2131)
- Kuan‐Pin Su (ORCID: https://orcid.org/0000-0002-4501-2502)
- Jeanette M. Johnstone (ORCID: https://orcid.org/0000-0003-3947-5540)
- Felice Nellie Jacka (ORCID: https://orcid.org/0000-0002-9825-0328)
- Jessica Bayes (ORCID: https://orcid.org/0000-0003-0601-6129)
- Wolfgang Marx (ORCID: https://orcid.org/0000-0002-8556-8230)
- Caroline Wallace (ORCID: https://orcid.org/0000-0001-8960-756X)
- Marjolein Visser (ORCID: https://orcid.org/0000-0002-5136-298X)
- Adrienne O’Neil (ORCID: https://orcid.org/0000-0002-4811-5830)
- Julia J. Rucklidge (ORCID: https://orcid.org/0000-0003-3793-7342)
- Rachelle Opie (ORCID: https://orcid.org/0000-0002-3816-0670)
- Michael Berk (ORCID: https://orcid.org/0000-0002-5554-6946)
- David Mischoulon (ORCID: https://orcid.org/0000-0001-7233-5860)
- Meghan Hockey (ORCID: https://orcid.org/0000-0003-2091-956X)
- Ana C. Villegas (ORCID: https://orcid.org/0000-0002-0432-0373)
Institutions
- Harvard University (US)
- Deakin University (AU)
- University of Ottawa (CA)
- Oregon Health & Science University (US)
- Universidad Pública de Navarra (UPNA) (ES)
- China Medical University (TW)
- University of Canterbury (NZ)
- Royal North Shore Hospital (AU)
- Instituto de Salud Carlos III (ES)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- UNSW Sydney (AU)
- Massachusetts General Hospital (US)
- An-Nan Hospital (TW)
- Navarre Institute of Health Research (ES)
- China Medical University Hospital (TW)
- Southern Cross University (AU)
- Vrije Universiteit Amsterdam (NL)
- Macquarie University (AU)
Publication Details
- Journal
- British Journal Of Nutrition
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1017/s0007114524001946
- Citations
- 7
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Wilson Foundation
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Sanofi
- Massachusetts General Hospital
- Geelong Region Medical Research Foundation
- PA Research Foundation
- David and Elaine Potter Foundation
- Verdure Sciences
- Bond University
- Australian Rotary Health
- Ian Potter Foundation
- Meat and Livestock Australia
- La Trobe University
- Deakin University
- University of Melbourne
- Servier
- H. Lundbeck A/S
- Fernwood Foundation
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- Cancer Council Queensland
- Brain and Behaviour Research Institute, University of Wollongong
- National Institute of Mental Health
- National Center for Complementary and Integrative Health
- Cilag