Case report: Identification of a novel TOR1AIP2::ETV6 transcript with FLT3-ITD mutation in acute myeloid leukemia progressed from myelodysplastic syndrome
Acute myeloid leukemia (AML), which is most common in adults, is a challenging hematological malignancy. The occurrence and the progression of AML are often accompanied by various gene fusions and/or mutations. Herein, we report the first case of a <i>TOR1AIP2::ETV6</i> fusion transcript with a translocation of <i>t</i>(1;12)(q25;p13) in AML progressed from myelodysplastic syndrome (MDS) combined with an <i>FLT3</i>-ITD (internal tandem duplication) mutation. Further studies should focus on the biological functions of these novel chimeric products in disease onset and progression, as well as their potential as monitoring markers in disease regression.
Authors
- Kaili Gu
- Lingling Wang (ORCID: https://orcid.org/0000-0002-1049-9170)
- Heng Chen (ORCID: https://orcid.org/0000-0001-6939-7665)
- Ping Chen (ORCID: https://orcid.org/0000-0001-7815-7532)
- Ge Li (ORCID: https://orcid.org/0000-0001-9030-884X)
- Qingling Yu
- Ruiyi Zhang (ORCID: https://orcid.org/0000-0002-4776-6762)
- Chao Sun
- Hongli Sun (ORCID: https://orcid.org/0000-0002-0719-6013)
- Guanqun Yang (ORCID: https://orcid.org/0000-0003-4536-664X)
- Jun Xia (ORCID: https://orcid.org/0000-0002-5689-0343)
- Man Wang (ORCID: https://orcid.org/0000-0001-7190-4582)
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Changshu No.1 People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.3389/fonc.2024.1466590
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00