AMBRA1 drives gastric cancer progression through regulation of tumor plasticity
Our findings uncover an oncogenic role for AMBRA1 in STAD. Targeting AMBRA1 may induce tumor cell senescence, apoptosis, and potentiate anti-tumor immunity, providing a rationale for developing AMBRA1-targeted precision therapies to improve clinical outcomes in STAD patients.
Authors
- Shiji Chen
- Danlei Lin (ORCID: https://orcid.org/0009-0002-7098-6816)
- Xiaoxu Liang (ORCID: https://orcid.org/0000-0002-3252-3418)
- Hai‐Jing Zhong (ORCID: https://orcid.org/0000-0002-1247-3150)
- Cheong‐Meng Chong (ORCID: https://orcid.org/0000-0002-2462-4729)
- Wen Zhang (ORCID: https://orcid.org/0000-0002-9352-6153)
- Yisong Zhen (ORCID: https://orcid.org/0000-0002-2386-6056)
- Linying Ye
- Sara Akkouche
Institutions
- Jinan University (CN)
- University of Macau (MO)
- Zhejiang Cancer Hospital (CN)
- Guangzhou Maritime College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.3389/fimmu.2024.1494364
- Citations
- 5
- Primary Topic
- Mechanisms of cancer metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.17