In silico neoantigen screening and HLA multimer-based validation identify immunogenic neopeptide in multifocal lung adenocarcinoma
This study provides an in-depth analysis of mutation characteristics of LUAD and establishes a neoantigen screening and validation system for identifying immunogenicity neopeptide across individual patients and diverse foci in the same patient with multifocal LUAD.
Authors
- Xiufang Weng (ORCID: https://orcid.org/0000-0003-2625-2137)
- Mi Wu (ORCID: https://orcid.org/0000-0003-3774-9624)
- Xiongwen Wu (ORCID: https://orcid.org/0000-0002-0155-3550)
- Lang Jiang (ORCID: https://orcid.org/0000-0003-3624-1618)
- Xin Wang (ORCID: https://orcid.org/0000-0001-8051-1481)
- Juan Zhao
- Jin Xiong
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.3389/fimmu.2024.1456209
- Citations
- 1
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Tongji University
- Tongji Medical College, Huazhong University of Science and Technology