Hematological Hemostatic Effects of Fractions of Dialium guineense Tree Bark in Ethanol-Induced Peptic Ulcer in Albino Rats

Background and Objective: Peptic Ulcer Disease (PUD) has been linked to several complications including disrupted hematological stability.This study aims to determine the hematological hemostatic effects of fractions of Dialium guineense stem bark in ethanol-induced ulcers in albino rats.Materials and Methods: Thirty rats were divided into six groups (five rats each) to assess biochemical effects.Group 1 was the normal control, receiving only food and water, while Group 2 (negative control) received ethanol alone.Group 3 received ethanol plus omeprazole, while Groups 4, 5 and 6 received ethanol combined with ethanol, methanol and n-hexane extracts, respectively, at 250 mg/kg body weight.Statistical analysis was performed using one-way ANOVA in SPSS, with significance set at p<0.05. Results:The results showed a significant (p<0.05)increase in the bleeding time and clotting time in the negative control with a concomitant significant (p<0.05)decrease in the bleeding time and clotting time across the co-treated groups.The same trend was noticed in the osmotic fragility and then in urea and creatinine concentration of the rats across the co-treated groups.Conclusion: It can be said that the seeds of Dialium guineense could contain active compounds that could improve the membrane integrity of red blood cells, improve platelet aggregation, increase blood coagulation and possibly accelerate wound healing.The mechanism is possibly through increasing PDGF-BB which is a growth factor released during platelet aggregation to activate the healing process.