Defining decision thresholds for judgments on health benefits and harms using the grading of recommendations assessment, development, and evaluation (GRADE) evidence to decision (EtD) frameworks: a randomized methodological study (GRADE-THRESHOLD)
Decision thresholds (DTs) help with determining if effects of interventions should be considered absent, small, moderate or large. In this study we derived an overarching approach for these thresholds across conditions and outcomes. The results of this study, a randomized experiment, will help guideline developers and other decision-makers to make these judgments objectively. They will be particularly relevant for the use in Grading of Recommendations Assessment, Development, and Evaluation (GRADE) evidence to decision (EtD) frameworks.
Authors
- Stefanos Bonovas (ORCID: https://orcid.org/0000-0001-6102-6579)
- Lawrence C. E. Mbuagbaw (ORCID: https://orcid.org/0000-0001-5855-5461)
- Pablo Alonso‐Coello (ORCID: https://orcid.org/0000-0002-8001-8504)
- Elie A. Akl (ORCID: https://orcid.org/0000-0002-3444-8618)
- Robby Nieuwlaat (ORCID: https://orcid.org/0000-0002-5267-7748)
- Wojtek Wiercioch (ORCID: https://orcid.org/0000-0001-6576-1650)
- Antonio Bognanni (ORCID: https://orcid.org/0000-0003-0128-903X)
- Daniele Piovani (ORCID: https://orcid.org/0000-0002-1414-6639)
- Grigorios I. Leontiadis (ORCID: https://orcid.org/0000-0001-5072-7599)
- Gian Paolo Morgano (ORCID: https://orcid.org/0000-0001-7577-7963)
- Reem A. Mustafa (ORCID: https://orcid.org/0000-0002-2091-0875)
- Thomas Piggott (ORCID: https://orcid.org/0000-0003-1643-5386)
- Holger J. Schünemann (ORCID: https://orcid.org/0000-0003-3211-8479)
- Kevin Pottie (ORCID: https://orcid.org/0000-0002-1874-8346)
- Natalia Celedón (ORCID: https://orcid.org/0000-0003-0782-8882)
- Marta Rigoni (ORCID: https://orcid.org/0000-0002-0530-9491)
- Ignacio Neumann (ORCID: https://orcid.org/0000-0001-8406-6880)
Institutions
- Western University (CA)
- Humanitas University (IT)
- University of Milan (IT)
- European Commission (BE)
- McMaster University Medical Centre (CA)
- Hospital de Sant Pau (ES)
- San Sebastián University (CL)
- Queens University (BD)
- Ministry of Health (CL)
- Iberoamerican Cochrane Centre (ES)
- Impact (CA)
- IRCCS Humanitas Research Hospital (IT)
- McMaster University (CA)
- American University of Beirut (LB)
Publication Details
- Journal
- Journal of Clinical Epidemiology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1016/j.jclinepi.2024.111639
- Citations
- 9
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 10.16