In search of herbistasis: COT-metsulfuron methyl displays rare herbistatic properties
Weed management is an essential intervention for maintaining food security and protecting biodiversity but is heavily reliant on chemical control measures (<i>i.e.</i>, herbicides). Concerningly, only one herbicide has been developed with a new mode of action (MOA) since the 1980s. Therefore, alternative strategies for preventing weed growth need to be explored. The lesser-known concept of halting weed growth through herbistasis could be one strategy to alleviate the lack of success in obtaining new MOA leads, but this type of activity has rarely been investigated. Herein reported is a bioisosteric cyclooctatetraene (COT) for phenyl ring replacement tactic, using the commercial acetolactate synthase (ALS) inhibitor metsulfuron methyl, that has unearthed a rare agent displaying herbistatic properties against the weed, <i>Cryptostegia grandiflora</i> (rubber vine).
Authors
- Jed M. Burns (ORCID: https://orcid.org/0000-0001-7872-1420)
- Gimme H. Walter (ORCID: https://orcid.org/0000-0003-1025-7101)
- Thierry Lonhienne (ORCID: https://orcid.org/0000-0001-8788-2840)
- Isobella S. J. Stone (ORCID: https://orcid.org/0000-0002-9474-4961)
- Hui Xing (ORCID: https://orcid.org/0000-0002-1631-1167)
- Sharon Chow (ORCID: https://orcid.org/0000-0001-8193-3504)
- Cody-Ellen Murray
- Tyler Fahrenhorst‐Jones (ORCID: https://orcid.org/0000-0002-8461-774X)
- Craig M. Williams (ORCID: https://orcid.org/0000-0002-3834-7398)
- G. Paul Savage (ORCID: https://orcid.org/0000-0001-7805-8630)
- Sevan D. Houston (ORCID: https://orcid.org/0000-0002-9309-7037)
- Amanda Nouwens (ORCID: https://orcid.org/0000-0003-4069-8266)
- Michelle A. Rafter (ORCID: https://orcid.org/0000-0002-5180-0062)
- Bruna Durante Batista (ORCID: https://orcid.org/0000-0002-8127-4665)
- Sarah K. M. McGregor (ORCID: https://orcid.org/0000-0002-5797-4119)
- Luke W. Guddat (ORCID: https://orcid.org/0000-0002-8204-8408)
- Yizhou Liu (ORCID: https://orcid.org/0000-0001-7456-4069)
- Shuhong Hu (ORCID: https://orcid.org/0000-0002-3878-1469)
- Qi Zhao (ORCID: https://orcid.org/0000-0002-4649-9527)
- Cassidy Whitefield
- Rebecca M. Hurst
Institutions
- The University of Queensland (AU)
- CSIRO Health and Biosecurity (AU)
- CSIRO Manufacturing (AU)
Publication Details
- Journal
- Chemical Science
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1039/d4sc06923d
- Citations
- 4
- Primary Topic
- Weed Control and Herbicide Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- Australian Government
- Department of Agriculture, Fisheries and Forestry, Australian Government
- Commonwealth Scientific and Industrial Research Organisation
- University of Queensland
- Queensland Government
- Department of Agriculture and Water Resources, Australian Government