Downregulated DKK2 may serve as a molecular mechanism of high-fat diet-induced myocardial injury via Wnt/β-catenin pathway
Activating DKK2 may serve as a novel therapeutic intervention option for obesity cardiomyopathy and obesity-related metabolic disorders, and future studies are needed to validate this hypothesis.
Authors
- Yu Nie (ORCID: https://orcid.org/0000-0002-8744-0046)
- Cuixing Yi
- Jiahao Shi (ORCID: https://orcid.org/0000-0002-6385-2468)
- Yan Pu
- Liyuan Zhang (ORCID: https://orcid.org/0000-0002-7469-1743)
- Di Chen (ORCID: https://orcid.org/0000-0002-2181-4703)
- Yixuan Wang (ORCID: https://orcid.org/0000-0002-7436-1429)
- Guangxiang Yang (ORCID: https://orcid.org/0000-0001-5020-8318)
- Qin Yu (ORCID: https://orcid.org/0000-0002-5703-8646)
- Jie Chen (ORCID: https://orcid.org/0000-0002-2916-4952)
- Yang Cui (ORCID: https://orcid.org/0000-0002-5880-5130)
- Xiaowei Wei (ORCID: https://orcid.org/0000-0002-3802-7845)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1016/j.lfs.2024.123306
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00