Bimetallic Pd-Au nanoparticles decorated MoS2/GO nanoflowers for sensitive detection of doxorubicin

Doxorubicin (DOX) was an anticancer drug that had widespread use in treating tumor cells, its excessive use leaded to several adverse effects, including hair loss, cardiotoxicity, and suppression of bone marrow hematopoiesis. Herein, we designed and prepared ultrathin Pd-Au NPs anchored on the surfaces of flower-like MoS 2 /GO to formation Pd (4) -Au (3) /MoS 2 /GO nano-catalysts. The obtained Pd (4) -Au (3) /MoS 2 /GO nano-catalysts were characterized by scanning electron microscope (SEM) and X-ray diffractometer (XRD). The numerous ultrathin walls containing both GO and MoS 2 nanolayers were interconnected to form flower-like MoS 2 /GO. The large specific surface area and interwoven pore structure were conducive to the loading of a large number of Pd and Au nanoparticles (NPs). The excellent hierarchical structure could possess more active sites and transportation channels to adsorb and diffuse of target analyte. Then Pd (4) -Au (3) /MoS 2 /GO nano-catalysts was used as sensing materials for sensitive DOX detection. The Pd (4) -Au (3) /MoS 2 /GO electrochemical-sensing properties and detection mechanism to DOX were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results showed that Pd (4) -Au (3) /MoS 2 /GO possessed excellent electrochemical catalysts activity and the electrode reaction was a an adsorption controlled process. The linear detection ranges of 0.11–127.5 μM, the detection limits was 0.042 μM. The prepared electrode had been successfully applied to the determination of DOX in urine sample with the recoveries were between 101.5 % and 106.4 %.