Overproduction of Mitochondrial Fission Proteins and Mitochondrial Fission in Podocytes of Lupus Nephritis Patients
Mitochondrial fission was observed in LN patients' podocytes. Mitochondrial fission proteins Drp1 and Fis1 were overproduced in podocytes, and then they can lead to mitochondrial fission, which may aggravate podocyte damage and proteinuria. While the mechanism still needs to be explored.
Authors
- Zhihan Chen (ORCID: https://orcid.org/0000-0002-4279-4553)
- Lei Xiong (ORCID: https://orcid.org/0000-0001-8739-4660)
- Qijiao Wei (ORCID: https://orcid.org/0000-0002-7791-0630)
- Xinchen Wu
- Lin He (ORCID: https://orcid.org/0000-0002-3979-8561)
- Na Wang (ORCID: https://orcid.org/0000-0002-8314-9972)
Institutions
- Yunnan University (CN)
- Fujian Provincial People's Hospital (CN)
- Fujian Provincial Hospital (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s497813
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.47