Prospective Observational Study of Sympathetic Failure as a Mechanism Associated with Bradycardia During Induction of General Anesthesia in Children with Down Syndrome
More than half of children with DS undergoing inhalation anesthesia induction with sevoflurane experienced bradycardia. Bradycardia and hypotension were associated with sympathetic failure. Sympathetic activity therefore appears to be a modifiable target in the prevention of bradycardia in children with DS.
Authors
- SidneyG. Marcum
- Kristie Geisler (ORCID: https://orcid.org/0000-0002-6053-4165)
- Qing Duan (ORCID: https://orcid.org/0000-0003-4467-7024)
- Lili Ding (ORCID: https://orcid.org/0000-0003-2345-3726)
- Jamie W. Sinton (ORCID: https://orcid.org/0000-0002-9906-1895)
- Jareen Meinzen‐Derr (ORCID: https://orcid.org/0000-0001-7765-6006)
- David S. Cooper (ORCID: https://orcid.org/0000-0002-4631-0472)
- John J. McAuliffe
- Susan Wiley
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- The Journal of Pediatric Research
- Published
- 2024-12-10
- DOI
- https://doi.org/10.4274/jpr.galenos.2024.87528
- Primary Topic
- Cardiovascular Syncope and Autonomic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cincinnati Children's Hospital Medical Center
- National Institutes of Health
- National Center for Advancing Translational Sciences