Differential circulating miRNA profiles identified miR-423-5p, miR-93-5p, and miR-4532 as potential biomarkers for cholangiocarcinoma diagnosis

Differential plasma cir-miRNA profile showed at least three candidates including miR-423-5p, miR-93-5p, and miR-4532 as potential biomarkers. From validation of these cir-miRNAs by RT-qPCR, the result showed that the satisfied sensitivity and specificity to differential CCA group from HC and OV group was obtained from miR-4532 (<i>P</i> < 0.05) while miR-423-5p and miR-93-5p can be used for differential CCA from OV and HC group (<i>P</i> < 0.05) with high specificity but limited the sensitivity. In conclusion, candidate cir-miRNAs have been identified as potential biomarkers including miR-423-5p, miR-93-5p and miR-4532. Screening by miR-4532 and confirmed with miR-423-5p, miR-93-5p were suggested for differential CCA patients in the endemic area of <i>O. viverrini</i>.

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Publication Details

Journal
PeerJ
Published
2024-12-10
DOI
https://doi.org/10.7717/peerj.18367
Citations
4
Primary Topic
Cholangiocarcinoma and Gallbladder Cancer Studies
Type
article
Field-Weighted Citation Impact
2.29

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article

Differential circulating miRNA profiles identified miR-423-5p, miR-93-5p, and miR-4532 as potential biomarkers for cholangiocarcinoma diagnosis

Kittiya Supradit, Kritiya Butthongkomvong, Sattrachai Prasopdee, Veerachai Thitapakorn et al.
4 citations
PeerJ
Cholangiocarcinoma and Gallbladder Cancer Studies
2.29
article

Differential circulating miRNA profiles identified miR-423-5p, miR-93-5p, and miR-4532 as potential biomarkers for cholangiocarcinoma diagnosis

Kittiya Supradit, Kritiya Butthongkomvong, Sattrachai Prasopdee, Veerachai Thitapakorn, Teva Phanaksri, Sithichoke Tangphatsornruang, Kanokpan Wongprasert, Montinee Pholhelm, Smarn Tesana, Siraphatsorn Yusuk, Jutharat Kulsantiwong, Amnat Chukan
article en
4 citations

Abstract

Differential plasma cir-miRNA profile showed at least three candidates including miR-423-5p, miR-93-5p, and miR-4532 as potential biomarkers. From validation of these cir-miRNAs by RT-qPCR, the result showed that the satisfied sensitivity and specificity to differential CCA group from HC and OV group was obtained from miR-4532 (<i>P</i> < 0.05) while miR-423-5p and miR-93-5p can be used for differential CCA from OV and HC group (<i>P</i> < 0.05) with high specificity but limited the sensitivity. In conclusion, candidate cir-miRNAs have been identified as potential biomarkers including miR-423-5p, miR-93-5p and miR-4532. Screening by miR-4532 and confirmed with miR-423-5p, miR-93-5p were suggested for differential CCA patients in the endemic area of <i>O. viverrini</i>.

PeerJVol. 12
Thammasat University (TH), National Science and Technology Development Agency (TH), Mahidol University (TH), Udon Thani Rajabhat University (TH), Udon Thani Hospital (TH), Ramkhamhaeng University (TH), National Center for Genetic Engineering and Biotechnology (TH)
Thammasat University
Good health and well-being
Openalex Percentile: Top 11%
Cholangiocarcinoma and Gallbladder Cancer Studies
2.29
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